Summary: The ECS plays an important role in stress and inflammation, which are a part of almost every single health problem. Targeting the ECS with medical cannabis could potentially help treat a number of symptoms associated with stress due to its immunomodulatory effects. Stress leads to inflammation. Inflammation plays a key role in the etiology of almost all health problems, and there’s even the idea that inflammation is a unifying theory of disease. Stress also alters memory functions, reward mechanisms, immune function, metabolism, and susceptibility to diseases.